MicroFlow kits significantly improve the speed and objectivity of scoring samples during a routine safety evaluation known as the Micronucleus Test. The in vivo Micronucleus Test is widely accepted by international regulatory bodies as a way of measuring DNA damage in red blood cells. MicroFlow data is accepted by the US FDA, and this method addresses all recommendations made by the International Workshop on Genotoxicity Test Procedures (IWGTP).

Why Choose MicroFlow (in vivo)?
This FDA-accepted method offers researchers a clear advantage over traditional microscopic methods. Some of the more significant benefits include:

• Speed: If you work within a fast-paced, competitive research environment, your research can leap ahead by three to six weeks each time you perform an in vivo micronucleus test. Results from scoring a complete test (60 samples) are typically obtained in just one day. Compared to microscopic methods, MicroFlow kits allow many more samples to be analyzed in less time.
• Flexibility: By simply taking a few drops of blood, MicroFlow kits can easily offer another significant endpoint to existing animal studies. Micronucleus testing can be conducted earlier in the development process, allowing for identification of compounds that induce micronuclei. In this way, a researcher can obtain the most data from each animal while also reducing overall costs and animal use.
• Better Statistics: With the use of flow cytometry, the incidence of micronuclei is determined within a population of 20,000 reticulocytes (versus only 2,000 by microscopic methods). The MicroFlow method is reliable and transferable.
• Value: In addition to receiving faster results, when you also consider the benefits of speed, flexibility, and better data, it becomes clear the value of this method far outweighs any alternative.

• Pharmaceutical companies (preclinical testing / clinical trials / post market surveillance)
• Contract Research and Testing Organizations (CROs and CTOs)
• Biotechnology research organizations
• University and academic research laboratories
• Government institutes and the military
• Medical and dental device manufacturers
• Chemical and tobacco companies

For researchers who work within very tight time constraints, faster and more reliable testing can be the difference between breakthroughs and disappointments.