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| MicroFlowBASIC Kit |
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Ship samples to Litron for flow cytometric
analysis. |
| MicroFlowPLUS Kit |
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Analyze in vivo samples using your own flow cytometer. |
MicroFlow® Kits
(in vivo)
Micronucleus Testing at the Speed
of LightMicroFlow kits significantly improve
the speed and objectivity of scoring samples during a routine
safety evaluation known as the Micronucleus Test. The in
vivo Micronucleus Test is widely accepted by international
regulatory bodies as a way of measuring DNA damage in red blood
cells. MicroFlow data is accepted by the US FDA, and this method
addresses all recommendations made by the International Workshop
on Genotoxicity Test Procedures (IWGTP).
Why Choose MicroFlow
(in vivo)?
This FDA-accepted method offers
researchers a clear advantage over traditional microscopic methods.
Some of the more significant benefits include:
- Speed: If you work within
a fast-paced, competitive research environment, your research
can leap ahead by three to six weeks each time you
perform an in vivo micronucleus test. Results from
scoring a complete test (60 samples) are typically obtained
in just one day. Compared to microscopic methods,
MicroFlow kits allow many more samples to be analyzed in
less time.
- Flexibility: By simply
taking a few drops of blood, MicroFlow kits can easily offer
another significant endpoint to existing animal studies.
Micronucleus testing can be conducted earlier in the development
process, allowing for identification of compounds that induce
micronuclei. In this way, a researcher can obtain the most
data from each animal while also reducing overall costs
and animal use.
- Better Statistics: With
the use of flow cytometry, the incidence of micronuclei
is determined within a population of 20,000 reticulocytes
(versus only 2,000 by microscopic methods). The MicroFlow
method is reliable and transferable.
- Value: In addition to
receiving faster results, when you also consider the
benefits of speed, flexibility, and better data, it
becomes clear the value of this method far outweighs any
alternative.
Who Should Use In Vivo MicroFlow
Kits?
- Pharmaceutical companies (preclinical
testing / clinical trials / post market surveillance)
- Contract Research and Testing
Organizations (CROs and CTOs)
- Biotechnology research organizations
- University and academic research
laboratories
- Government institutes and the
military
- Medical and dental device manufacturers
- Chemical and tobacco companies
For researchers who work within very
tight time constraints, faster and more reliable testing can
be the difference between breakthroughs and disappointments.
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