Measure
DNA damage in red blood cells
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This test detects damage to the chromosomes, or spindle
apparatus, of cells. After exposure to a test substance,
precursor cells divide. It is upon division that this
type of damage can result in the formation of a smaller
‘micronucleus', apart from the main nucleus.
At this point, red blood
cells expel their main nuclei. When stained, micronuclei
(which contain DNA) are easily seen in a population
of cells with no nuclear DNA. These ‘micronuclei’ are
also referred to as Howell-Jolly Bodies (HJB).
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MicroFlow®
Kits
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Litron's MicroFlow kits
use flow cytometry to analyze micronuclei in human blood
samples. This method is based on Litron’s rodent micronucleus
kits.
Anti-CD71 antibodies
distinguish between mature and immature RBCs. Micronuclei
are easily identified with a DNA stain.
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Click Image to Enlarge
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Disclaimer
The methods for human blood analyses by MicroFlow are
for Research Use Only (RUO) and have
not been approved, cleared, validated or intended for
clinical diagnostic use or to serve as a basis for individual
patient management.
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Examine trends or changes in
populations
- Environmental exposure
- Workplace safety
- Clinical research
- Post-market surveillance
- Other epidemiological studies
I want to measure micronuclei
in human blood. Can you help me?
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Yes. Blood samples can
be shipped to us for flow cytometric analysis. For information
on how to send samples for this method, contact us.
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Can I measure micronuclei at
my own facility?
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Currently, this method
is only offered as a service at Litron.
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For more information, see
these
selected journal articles.
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