Human Micronucleus
Scoring

Measuring DNA Damage
in Red Blood Cells

Exposure to a test substance can result in damage to the chromosomes or spindle apparatus of cells. During routine cell division, this type of damage can create a smaller ‘micro’-nucleus, apart from the main nucleus.

When red blood cells mature themain nucleus is expelled. Micronuclei remain behind, and can easily be seen in a cell with no other DNA. This makes red blood cells ideal for measuring this endpoint.

In human blood, these ‘micronuclei’ are sometimes referred to as Howell-Jolly Bodies (HJB).

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Features

  • Requires Minimal Amounts of Blood
    Collect approximately 120 µl of blood per sample.
  • Takes Advantage of Magnetic Columns
    Enrich samples by separating young and old red blood cells.
  • Includes Calibration Standards
    Malaria Biostandards ensure proper flow cytometric setup.
  • Analysis by Flow Cytometry
    Automated scoring provides objective and reproducible results.

Benefits

  • Easily Integrate with Existing Studies
    Use with epidemiological studies or clinical trials.
  • Measure Very Rare Events
    This is the first time this endpoint has been available for routine use!
  • Provides Reproducible Data
    Calibration standards ensure confidence in your results.
  • Fast Turn Around, Reliable Results
    Get your data as soon as possible using laser-based technology.

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Clinical Research
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Environmental exposure
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Post-market surveillance
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Workplace safety
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Other epidemiological studies

I want to measure micronuclei in human blood. Can you help me?


Yes. Blood samples can be shipped to us for flow cytometric analysis. For more information, please contact us.

Disclaimer

MicroFlow analysis of human blood is for
Research Use Only (RUO) and has not
been approved, cleared, validated or intended
for clinical diagnostic use or to serve as
a basis for individual patient management.

Unlimited Technical Support

Speak with the scientists who designed the method
•
Unlimited phone and email technical support
•
Training, at your site or ours

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