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Micronucleus Scoring
Overcoming the serious limitations of microscopic scoring, the MicroFlow method provides speed and objectivity as well as an unprecedented level of reproducibility in the data. By analyzing thousands of cells per second, 20,000 cells can be routinely scored per sample (versus only 2,000 with microscopy), providing much tighter standard deviations. With this proven flow cytometric method, an entire micronucleus test may now be scored in just one day, offering researchers the ability to keep up with sharply rising demand.In Vivo
The in vivo MicroFlow method supports
a variety of species (for more information, please inquire).
- Faster Results: Results from scoring a complete test are typically obtained in just one day.
- Superior Data: Automated scoring of 20,000 reticulocytes per sample (versus only 2,000 by traditional methods).
- Greater Value: With a few drops of blood, MicroFlow kits can easily offer another significant endpoint to existing animal studies.
In Vitro
The in vitro MicroFlow method supports
a wide range of cell lines, both attachment and suspension,
including L5178Y, CHO-K1, TK6 and V79 among others. Ongoing
investigations include other test systems such as human peripheral
blood lymphocytes and 3D human skin models. These In Vitro MicroFlow
kits offer researchers a number of clear advantages:
- Faster Results: Results from scoring a complete test are typically obtained in just one day. This much higher throughput offers the ability to screen more compounds per week, or per month, than is possible using traditional methods.
- Superior Data: Using the In Vitro MicroFlow method, micronucleus data are reproducible to a degree not possible with simple microscopic scoring. Micronucleus counts are determined within a population of 20,000 healthy nuclei (versus only 2,000 by traditional methods).
- High Content: Along with micronucleus measurements, this method also offers superior bead-based cytotoxicity assessment (Relative Survival), the percentage of dead/dying cells and cell cycle information.
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